CAS number 111470-99-6
Amlodipine besylate is the besylate salt of amlodipine, a long-acting calcium channel blocker.
Amlodipine besylate is chemically described as 3-Ethyl-5-methyl (±)-2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate, monobenzenesulphonate. Its molecular formula is C20 H25 ClN2 O5 ·C6 H6 O3 S
Amlodipine besylate is a white crystalline powder with a molecular weight of 567.1. It is slightly soluble in water and sparingly soluble in ethanol. Amlodipine besylate tablets are formulated as white tablets equivalent to 2.5, 5 and 10 mg of amlodipine for oral administration. In addition to the active ingredient, amlodipine besylate, each tablet contains the following inactive ingredients: colloidal silicon dioxide, dibasic calcium phosphate anhydrous, magnesium stearate, microcrystalline cellulose, sodium starch glycolate, and stearic acid.
Formula Structure:
Systematic (IUPAC) name
(RS)-3-ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
Identifiers
CAS number 111470-99-6
ATC code C08CA01
PubChem CID 2162
DrugBank APRD00520
ChemSpider 2077
UNII 1J444QC288
Chemical Data
Formula C20H25ClN2O5
Mol. mass 408.879 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic Data
Bioavailability 64 to 90%
Metabolism Hepatic
Half-life 30 to 50 hours
Excretion Renal
Therapeutic considerations
Pregnancy cat. C(AU) C(US)
Legal status POM (UK) ?-only (US)
Routes Oral (tablets)
Amlodipine Besylate – Taj Ando Pharmaceuticals, South Africa | Amlodipine besylate is a white crystalline powder with a molecular weight of 567.1. It is slightly soluble in water and sparingly soluble in ethanol. Amlodipine besylate tablets are formulated as white tablets equivalent to 2.5, 5 and 10 mg of amlodipine for oral administration. In addition to the active ingredient, amlodipine besylate, each tablet contains the following inactive ingredients.
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